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However, cortisol has been shown to inhibit resorption in bone organ culturesand bone marrow harvested from mice treated with prednisolone showed reduced osteoclastogenic potential
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The Fc fusion partner maintains the potent dimeric nature of OPG while significantly increasing its circulating half-life.
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Treatment with denosumab resulted in a mean increase in BMD at the lumbar spine of 3. A heparin binding domain at the carboxy-terminus of OPG limits the half-life and distribution of the molecule, and this domain is also involved in dimer formation.
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The most universally described skeletal consequence of glucocorticoid therapy is a reduction in BMD, which can lead to increased fracture risk —
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Numerous growth factors, hormones, cytokines and drugs have been shown to influence the expression of OPG and RANKL, and an excellent summary of these regulatory responses was described recently 15 Table 2.
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